Introduction

Tretinoin, also known as all-trans retinoic acid, is a first-generation retinoid widely used in dermatology. The 0.05% formulation represents a common concentration for topical application, balancing efficacy and tolerability. This report provides a detailed examination of tretinoin 0.05%, including its pharmacology, indications, clinical efficacy, side effects, and practical usage guidelines.

Mechanism of Action

Tretinoin exerts its effects by binding to nuclear retinoic acid receptors (RARs), specifically RAR-α, 200mg Portugal